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CJC-1295 was engineered with modifications that extend it to days either through a DAC (Drug Affinity Complex) modification that enables albumin binding, or without DAC for a shorter but still extended duration

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Clinical practice guidelines suggest several scenarios where dose modification may be appropriate: Persistent gastrointestinal symptoms lasting beyond the first week of a new dose level may warrant extending that dose phase by an additional 2-4 weeks before further escalation